Functionalization of multi-walled carbon nanotubes with coumarin derivatives and their biological evaluation.

نویسندگان

  • Daniela Iannazzo
  • Anna Piperno
  • Angelo Ferlazzo
  • Alessandro Pistone
  • Candida Milone
  • Maurizio Lanza
  • Francesco Cimino
  • Antonio Speciale
  • Domenico Trombetta
  • Antonina Saija
  • Signorino Galvagno
چکیده

We report the synthesis and the characterization of different multi-walled carbon nanotubes (MWCNTs) linked to natural molecules, 5,7-coumarins and/or oleic acid, obtained from purified pristine MWCNTs by a cascade of chemical functionalization. The activities of these modified MWCNTs were investigated in vitro on human umbilical vein endothelial cells (HUVECs) by evaluating their ability to influence cell viability and to induce cell apoptosis. Our data showed that pristine MWCNTs are markedly cytotoxic; conversely, the carboxylated carbon nanotubes, much more readily dispersed in aqueous solutions and CNT-Link, the key intermediate designed by us for the drug anchorage, are biocompatible at the tested concentrations (1 and 10 μg ml(-1)).

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 10 5  شماره 

صفحات  -

تاریخ انتشار 2012